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DeCS
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Descriptor English:
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Activin Receptors
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Descriptor Spanish:
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Receptores de Activinas
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Descriptor Portuguese:
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Receptores de Ativinas
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Synonyms English:
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Activin Receptor
Activin Receptor like Kinase
Activin Receptor like Kinases
Activin Receptor-Like Kinases
Activin Receptor-like Kinase
Kinase, Activin Receptor-like
Kinases, Activin Receptor-like
Receptor, Activin
Receptor-like Kinase, Activin
Receptor-like Kinases, Activin
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Tree Number:
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D08.811.913.696.620.682.700.062
D12.776.543.750.750.400.820.500
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Definition English:
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Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity. |
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History Note English:
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2002; use ACTIVIN RECEPTORS (NM) 1991-2001
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Allowable Qualifiers English:
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Record Number:
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36116
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Unique Identifier:
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D029404
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Occurrence in VHL:
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Similar:
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DeCS
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